Advantage XD Large Cat Flea Prevention & Treatment For Cats over 9lbs. | 1-Topical Dose, 2-Months of Protection Per Dose
  • Advantage XD Large Cat Flea Prevention & Treatment For Cats over 9lbs. | 1-Topical Dose, 2-Months of Protection Per Dose
  • Advantage XD Large Cat Flea Prevention & Treatment For Cats over 9lbs. | 1-Topical Dose, 2-Months of Protection Per Dose
Brand Advantage
Item Form Topical
Scent Unscented
Age Range (Description) 8 weeks and older
Item Weight 22.68 Grams
Active Ingredients Spinetoram
Item Volume 2 Milliliters
Target Species Cat
Allergen Information Allergen-Free
  • 2 months (1 dose) flea treatment and prevention for indoor and outdoor cats or kittens over 9 lbs., 8 weeks or older
  • Longer-lasting protection vs. other topical products; 2 months protection per dose, outlasting the typical flea life cycle
  • Fast-acting treatment starts killing fleas through contact within 30 minutes to 4 hours
  • Easy-to-apply topical treatment, no prescription needed
  • Fragrance-free formula, containing a naturally derived ingredient Spinetoram - winner of a Green Chemistry award US EPA Presidential Green Chemistry Challenge. Designing Greener Chemicals Award. 2008.

Product Description

Cat lovers choose Advantage XD for double the lasting protection against fleas vs. other 1-month options. Advantage XD for large cats and kittens packs two full months of treatment and continuous protection in each dose, so your cat is protected for longer than the traditional 1-month formula. If your cat has already tousled with fleas, you’ll love that Advantage XD topical treatment starts killing fleas through contact in 30 minutes to 4 hours – that means fleas can be eliminated before they bite your cat. And with Advantage XD extended duration formula, that flea prevention remains effective for 8 weeks, outlasting the typical 6-week flea life cycle and preventing reinfestation. Find Advantage XD topical flea treatment available in a variety of pack sizes, from 2 months protection (1 dose), to 4 months protection (2 doses), or 8 months protection (4 doses). This fragrance-free formula contains Spinetoram, a naturally derived, Green Chemistry Award-winning* ingredient. Advantage XD flea infestation prevention is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage XD for large cats. Even with the squirmiest of kittens and cats, application is easy. The single, topical, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It's easier than a flea collar, and there are no hard-to-swallow pills; this topical treatment goes on in seconds. See product label for more information. For the ultimate convenience in care, Advantage XD is available over the counter – no prescription needed. Once Advantage XD is applied, your cat is ready to get right back to exploring the outdoors or finding a cozy spot for a nap, while you get to enjoy peace of mind. *US EPA Presidential Green Chemistry Challenge. Designing Greener Chemicals Award. 2008.

Product details

  • Product Dimensions ‏ : ‎ 4.75 x 4.25 x 0.88 inches; 0.8 ounces
  • Manufacturer recommended age ‏ : ‎ 1 month and up
  • Item model number ‏ : ‎ CA4242006AM
  • Date First Available ‏ : ‎ September 17, 2022
  • Manufacturer ‏ : ‎ Elanco US Inc
  • ASIN ‏ : ‎ B0BCX9NJS1
  • Country of Origin ‏ : ‎ USA
  • Best Sellers Rank: #2,027 in Pet Supplies (See Top 100 in Pet Supplies)
    • #13 in Cat Flea Drops
  • Customer Reviews:
    4.3 4.3 out of 5 stars 1,162 ratings

From the manufacturer

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Advantage XD protects indoor and outdoor cats from fleas

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Find the right treatment for your cat

Advantage XD for cats is for use on both indoor and outdoor cats and kittens 8 weeks of age and older and weighing 1.8 pounds or more.


Select the right size for your cat based on weight.

  • Small cat: 1.8-9 pounds
  • Large cat: more than 9 pounds

How to apply

1. Open applicator tube by twisting the nozzle tip.


2. Part the hair on the neck at the base of the head until the skin is visible.


3. Place the tip of the tube directly above the skin and squeeze the tube 2–4 times to expel the contents of the tube directly on the skin.


Avoid getting the product in your cat’s eyes or mouth.


Tips for best results

To kill fleas and prevent reinfestations, apply one applicator tube every two months.

  • Apply at the base of the head, not between shoulder blades. Treatment at the base of the head will minimize the opportunity for the cat to directly lick the product.
  • Be sure to use the entire tube of Advantage XD when applying it to your cat.
  • Do not split tubes between multiple cats.
See package insert for additional details.

Frequently Asked Questions

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How long does it take to work on fleas?

Fast acting Advantage XD starts to kill fleas in 30 minutes to 3 hours.


This extended duration formula remains effective for two months, outlasting the typical six-week flea life cycle and preventing re-infestation.

Does it expire?

There is no expiration date required on the packaging by the EPA for Advantage XD. The product should be kept in its original packaging and stored as directed on the label.

Why do I still see fleas after using Advantage XD?

The fleas you see on your pet today are not the same fleas that you initially saw when you applied the treatment. These are new fleas from the environment that have since developed into adults and jumped on your cat.


As the weeks go by, these developing stages should run their course and disappear. Be sure to treat your pet’s environment, including your home, yard, carpet, bedding, etc. to help prevent reinfestations.

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Advantage XD Large Cat Flea Prevention & Treatment For Cats over 9lbs. | 1-Topical Dose, 2-Months of Protection Per Dose

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